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By Ali S. Faqi (Auth.)

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G. ’ for further discussions on determining half-life. , half-life is a ‘dependent’ parameter [10,19]. After a simple rearrangement of Eq. 10), Eq. 21) shows the relationship between clearance, volume of distribution, and the elimination rate constant, lz . 21) Considering Eq. 20), solving for lz and substituting into Eq. 22) Thus, t1/2 will increase as CL decreases or Vd increases (Vz in this case). 22) is written specifically to highlight that CL and Vd, two independent parameters, both control t1/2 which is a dependent parameter.

1, recall that the volume of distribution was quite simple. An injection of a given amount of drug was made into a beaker. Then, a concentration was quantitated from a sample withdrawn from the beaker, and this value was used to calculate a volume. 1) was used (similar to Eq. 8)), and the volume calculated was the actual physical volume of the beaker. 2, the situation became more complex because drug was withdrawn from the beaker by the filter attached to the pump. However, at any given time, Eq.

1 where no filter was in place. , minutes or hours, will result in a lower concentration as the filter has reduced the amount of compound in the beaker. The filter in this example is analogous to the liver, which frequently removes a drug from circulation, and is a site of both drug excretion (via the bile) and metabolism. 2 A beaker that contains water which is continuously circulated and mixed by a pump. In this diagram, a filter has been introduced just before the pump. The filter removes compound from the water as it flows past.

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